THE IMPACT OF DELIVERY MODE ON MTCT OF HEPATITIS B VIRUS AFTER TENOFOVIR DISOPROXIL FUMARATE IMPLEMENTATION IN THAILAND

Abstract

The Hepatitis B virus remains a major public health problem around the world, especially in developing countries. In Asia, the prevalence of the hepatitis B virus is more than 8%. In Thailand, thousands of children under the age of 5 years have HBV infection from mother-to-child transmission.  Infants infected with HBV from their mothers are at risk of developing hepatocellular carcinoma and hepatic cancer at 90%. Since 2017, Thai national guidelines have recommended that mothers with high viral loads or HBeAg positivity use Tenofovir disoproxil fumarate (TDF) prevent HBV transmission to their babies. to evaluate the effect of TDF on the prevention of mother-to-child Hepatitis B transmission and mode of delivery in Thailand. However, there are few studies in Thailand on the effect of manner of delivery on mother-to-child transmission after TDF treatment.