EFFECTS OF COMBINATION TREATMENT OF LONG-PULSED ND: YAG 1064NM LASER WITH 15% GLYCOLIC ACID FOR FACIAL REJUVENATION

Abstract

This prospective interventional study investigated the effectiveness of combining long-pulsed Nd: YAG 1064nm laser with 15% glycolic acid for facial rejuvenation in 15 participants, Southeast Asian ethnicity, aged 35-50 years with Fitzpatrick skin types III-V. Each subject underwent 3 treatment sessions at four-week intervals, with outcomes assessed using the Physician Global Aesthetic Improvement Scale (GAIS) at weeks 4, 8, and 12, along with wrinkle severity, skin viscoelasticity, and trans-epidermal water loss (TEWL) from baseline to follow-up. Patient satisfaction was recorded at week 12, and adverse events were monitored throughout. Results demonstrated progressive improvements in GAIS, significant reductions in wrinkles, increased skin viscoelasticity, and decreased TEWL, reflecting enhanced dermal structure and barrier function. All participants expressed high to complete satisfaction, and no serious side effects such as scarring, hyperpigmentation, or prolonged erythema were reported. These findings indicate that the combined therapy is a safe, well-tolerated, and effective approach to facial rejuvenation, offering synergistic benefits by targeting both dermal remodeling and epidermal renewal pathways, and highlighting its potential as a valuable minimally invasive treatment option.