EVALUATION OF SATISFACTION AND ACCEPTABILITY OF A CENTELLA ASIATICA-BASED ORAL ULCER PATCH AMONG HEALTHY VOLUNTEERS

Abstract

This study evaluated the satisfaction with a standardized Centella asiatica-infused oral ulcer patch among healthy volunteers. A non-randomized, uncontrolled clinical trial was conducted at the Faculty of Dentistry, Prince of Songkla University, with 20 participants aged 18-65 years who applied a 1.40 cm patch to the inner lower lip for three hours. Satisfaction was assessed using patient-reported outcome measures (PROMs), covering ease of use, removal, adhesion, comfort, taste, texture, odor, overall satisfaction, and willingness for future use and recommendation. Most participants reported that the patch was easy or very easy to apply (75%) and remove (75%). Adhesion at the intended site was maintained throughout in 35% of cases, while 65% reported partial displacement without complete detachment. Odor received the highest satisfaction rating (90%), followed by taste (65%) and texture (70%). Overall satisfaction was reported by 70% of participants, and willingness to recommend the product to others was noted by 75%. Additionally, 65% expressed an intention to use it in the future. No serious adverse events occurred, with only mild and transient issues, such as temporary taste alteration or adhesion to adjacent teeth, reported. In conclusion, the C. asiatica-infused oral ulcer patch demonstrated favorable user satisfaction, ease of handling, and acceptability among healthy volunteers. Refinements in sensory attributes and adhesion may further improve the user experience.