THE DEVELOPMENT OF SUK SAI YAD REMEDY IN PILL DOSAGE FORM AND STABILITY STUDY OF ITS VARIOUS FORMS

Abstract

This study aimed to develop a pill dosage form of the Suk Sai Yad (SSY) remedy and to evaluate its stability in three dosage forms: powder, capsule, and pill. The SSY pill was successfully developed, with Formula 2 being identified as the most suitable formulation, consisting of 60.00% w/w SSY powder, 10.00% w/w glucose syrup, and 30.00% w/w distilled water. This formulation passed all physical tests and demonstrated the highest production yield at 71.39%. Subsequently, all three dosage forms of SSY were manufactured for further stability studies under both long-term and accelerated conditions. Comprehensive evaluations were conducted, including physical tests, chemical analysis, and microbial contamination testing. All samples passed the physical tests and met the microbial contamination criteria. For the chemical analysis, piperine remained stable for six months under both conditions in all dosage forms. In contrast, the gallic acid content decreased by more than 10% from its initial value only in the capsule dosage form under accelerated conditions at the six-month mark. Moreover, analysis of CBD and Δ⁹-THC revealed that only the SSY powder under long-term conditions maintained its content within ±10% of the initial levels throughout the six-month period. Therefore, it can be concluded that if piperine and gallic acid are used as markers in the accelerated stability study, a 2-year shelf life could be extrapolated for both the powder and pill forms. However, when considering all compounds, the long-term stability study shows that only the powder form has a shelf life of 6 months. Thus, it is necessary to investigate additional methods to slow the degradation of all four active compounds.