THE EFFICACY COMPARISON OF INTRADERMAL ONABOTULINUMTOXINA INJECTION BY DIFFERENT DILUTION TO REDUCE FACIAL SEBUM PRODUCTION

Abstract

This study aimed to compare the efficacy of intradermal injections of OnabotulinumtoxinA at two different dilutions on each side of face —2 Units/0.1 mL and 4 Units/0.1 mL—for reducing facial sebum production. Twelve healthy volunteers aged between 18 and 40 years were enrolled in a split-face study design, in which each side of the face received an equal total dose of botulinum toxin but with differing concentrations. Follow-up assessments were conducted at weeks 1, 4, and 8. The results demonstrated a statistically significant reduction in facial sebum levels from baseline within both groups (p < 0.001), with the greatest reduction observed at week 4. However, no statistically significant differences were found between the two concentrations in terms of sebum reduction, patient satisfaction, or adverse effects (p > 0.05). In conclusion, intradermal injections of OnabotulinumtoxinA at both concentrations are comparably effective and safe for facial sebum reduction.