SALIVARY BIOMARKERS IN PATIENTS UNDERGOING FIXED ORTHODONTIC TREATMENT: A SYSTEMATIC REVIEW

Abstract

Background: Saliva serves as a non-invasive, cost-effective, and convenient medium for the assessment of biochemical markers. These biomarkers have the potential to facilitate early disease detection, monitor physiological changes, and provide insights into orthodontic tooth movement, potentially preceding clinically observable changes. This systematic review aims to analyze the current literatures on salivary biomarkers in individuals undergoing fixed orthodontic treatment. Materials and Methods: A systematic literature search was conducted across PubMed, ScienceDirect, and Scopus databases. Only peer-reviewed studies involving human saliva samples from patients undergoing fixed orthodontic treatment were included. Results: From a total of 407 articles, five studies were systematically selected for this review. Sample sizes in the selected studies ranged from three to thirty participants. Thirteen salivary biomarkers were identified, primarily through mass spectrometry-based proteomic analyses and enzyme-linked immunosorbent assay (ELISA). Conclusion: Salivary proteomics represents a promising approach for monitoring therapeutic responses in patients undergoing orthodontic treatment.