THE EFFICACY OF 5% PROBIOTICS (LACTOBACILLUS) GEL IN REDUCTION OF SEBUM PRODUCTION

Abstract

Skin is the most external neuroendocrine organ of the body and is a habitat for many microbiomes. Among these, Propionibacterium acne (P.acne) is the most common species that causes increase sebum production which will lead to acne formation. P.acne hydrolyses di and tri-glycerides into FFA with the help of lipase which results in lowering of skin PH, increase sebum production, irritation and promote inflammation. Probiotics reduce the sebum production and decrease inflammation by blocking the growth of P.acne. The amount of volunteer needed will be 14. The age gap is between 18-40 and can be of both male & female. Explanation to volunteer and getting the written informed consent will be done before starting any procedure. The gel has to be taken about 5mg twice/day (one at morning, one at night). Follow up will be on 0,4th and 8th week. The volunteer has to come back to hospital and the researcher will monitor the sebum production condition & skin condition by using the sebumeter & the VISIA. If there is side effects like skin redness and irritation. The researcher will note down and take action at once.