LORAZEPAM VERSUS PLACEBO FOR REDUCTION OF ANXIETY AND POSTOPERATIVE PAIN IN PATIENT UNDERWENT THIRD MOLAR SURGERY: A DOUBLE-BLIND, RANDOMIZED CONTROL CLINICAL TRIAL

Abstract

The objective of this research was to evaluate the effectiveness of premedication with lorazepam on anxiety and post-operative pain reduction in outpatient third-molar surgery. This is a clinical research study, a randomized controlled trial (RCT) design, double-blinded, and split-mouth technique. There were 30 participants divided into two groups: Group A was premedication with lorazepam 0.5 mg before the first operation and with a placebo before the second operation, and Group B was premedication with a placebo before the first operation and lorazepam 0.5 mg before the second operation. Anxiety levels were assessed 1 day before surgery and on the operative day. Pain levels were measured at 2, 3, 4, 6, and 8 hours post-surgery. Before the analysis, the new study group was classified as the group that received lorazepam and a placebo. Results of this research showed that lorazepam significantly decreased anxiety levels compared to a placebo both one day before surgery and on the operative day. Furthermore, its effects persisted for a longer duration. Additionally, lorazepam effectively reduced pain levels at 4-6 hours post-surgery and demonstrated a more substantial reduction in pain at 2 hours post-surgery compared to the placebo group. So, Administration of lorazepam significantly reduces anxiety and pain more effectively than a placebo, and its therapeutic effects are sustained for a longer period compared to the placebo.