THE EFFICACY OF COMBINATION THERAPY OF FRACTIONAL PICOSECOND LASER AND 20% GLYCOLIC ACID PEELING FOR FACIAL REJUVENATION

Abstract

Human aging is characterized by skin laxity, wrinkles and depigmentation. Skin aging is a chronic process that is accelerated by UV radiation. Rejuvenation refers to the removal and regeneration of the skin, resulting in a more organized, "younger" dermal matrix and epidermal normalization. Picosecond lasers originally developed for tattoo removal and have proven effective in treating a variety of skin conditions. Glycolic Acid (GA) is a natural AHA with good skin penetration due to its hydrophilic properties and small size. To study the efficacy of a combination of fractional picosecond laser 1064 nm wavelengths and 20%glycolic acid peeling for facial rejuvenation. Twelve subjects, age 30-50 years with Fitzpatrick skin ranging from III to V who desire to undergo facial rejuvenation received 3 treatment sessions of 1064 fractional picosecond laser and glycolic acid combination with 2 weeks interval. Wrinkles, skin elasticity and trans epidermal water loss will be assessed at baseline and each 2nd, 4th, 8th and 12th week follow up visit accordingly. The combination of fractional picosecond laser 1964nm wavelengths and 20% glycolic acid peeling have better statistically significant results in wrinkles, skin elasticity and trans epidermal water loss. And the volunteers also gave satisfactory result after final treatment. This study pointed that the combination of fractional picosecond laser 1964nm wavelengths and 20% glycolic acid peeling method can get better outcomes than the mono therapies.